Opsonization of late apoptotic cells by Systemic Lupus Erythematosus (SLE) autoantibodies inhibits their uptake via an FcγR-dependent mechanism
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منابع مشابه
Anti-endothelial cell antibodies from lupus patients bind to apoptotic endothelial cells promoting macrophage phagocytosis but do not induce apoptosis.
OBJECTIVE Anti-endothelial cell antibodies (AECA) have been reported to induce apoptosis. We investigated the induction of apoptosis by these autoantibodies and their involvement in the removal of apoptotic cells. METHODS AECA isolated from patients with active systemic lupus erythematosus (SLE) were incubated with human umbilical vein endothelial cells (HUVECs). AECA-positive sera were ident...
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